Off the bat I'm going to state - and this is important - I am a HUGE fan of low ISO work. When you are wanting clarity, acuity and the best possible pixels with which to work base ISO (i.e. the lowest ISO on your camera, disregarding Nikon's 'Lo' settings) is the best possible place to start. BUT, photographic exposure is always, always, about compromise. It is simply impossible to have a fast shutter speed, tiny aperture and zero noise all on the same exposure (unless you have the sun strapped to your shoulder, which is unlikely unless you are the Egyptian God Ra). So there has to be some sort of compromise somewhere.
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